Monday 14 May 2018

3.1.5.2 DNA replication

The semi-conservative replication of DNA ensures genetic continuity between generations of cells. It takes place as follows:

  • The enzyme DNA helicase breaks the hydrogen bonds between the complementary base pairs of DNA
  • The double helix separates into two strands and unwinds (as a result)
  • Each exposed polynucleotide strand acts as a template to which complementary free nucleotides bind by specific base pairing
  • Nucleotides are joined together by DNA polymerase which forms the sugar-phosphate backbone in a condensation reaction
  • Each DNA molecule contains one new and one original strand, hence the name semi-conservative.

Watson and Crick devised this model of DNA replication. If i'm very honest, i'm not sure what the spec means by we need to be able to evaluate the work of scientists in validating this experiment(?). Please help if you know:)
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